Gustafsson, Kristin 0000-0003-3403-229x - DiVA

Medivir OARSI 2019 Forum Placera - Avanza

The dog is a common model for study of osteoarthritis (OA). Subjective histologic scoring systems have often served as the reference standard for presence and severity of OA. However, these scoring systems have perceived shortcomings. The system developed for this report attempts to address these shortcomings by providing a standardized methodology Objective: During the development of disease-modifying osteoarthritis (OA) drugs, rat models of OA are frequently used for a first assessment of in vivo efficacy. The most efficacious compound in the rat model may then be tested in a larger animal model before entering human trials. The aim of this study was to describe a histologic scoring system 2010-07-07 · OARSI has collected the most important indexes used by physicians and researchers to evaluate the algofunctional status of patients with chronic musculoskeletal diseases. Some of them are also relevant to evaluate the impact of pain on the patient’s psyche and on socio-professional relationships.

This method provides equal ordinal number weight to severity (grade) and to extent (stage). This OARSI recommended set of performance-based tests of physical function are best suited for older individuals (> 40 years) diagnosed with hip and/or knee osteoarthritis (OA), including end-stage disease or following joint replacement. They are intended for use by both clinicians and 2010-10-01 · In some of the recently published rat OA studies10, 30 the OARSI score 31 is used, which multiplies the cartilage damage score by a factor to reflect the extent of the tibial plateau that is involved. For a general histological assessment of OA in rats, a modified Mankin score, like the one described for guinea pigs in this issue, may be sufficient.

Next, allow the hands to be placed on their legs or use their regular mobility aid. If the person can stand with adaptions, then record the number of stands as an adapted test score (see score sheet). Indicate the adaptations made to the test.

Medivir OARSI 2019 Forum Placera - Avanza

For the histopathological classification of the severity of osteoarthritic lesions of cartilage, the Mankin score is frequently used. A necessary constraint on the validity of this scoring system 2 days ago While tomosynthesis showed no significant difference in OARSI score grading to CT (mean OARSI-score CT: 16.8, SD = 10.6; mean OARSI-score Tomosynthesis: 16.3, SD = 9.6; P = 0.84), conventional radiographs had significant lower mean OARSI scores (mean OARSI-score X-ray: 11.1, SD = 8.3; P = 0.04). The OARSI score has been used to describe changes occurring in induced or genetic OA mouse models but not to describe spontaneous age-related evolution of OA-type cartilage lesions in wild-type mice.

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If the affected population is considered alone, a significant difference (p < 0.001) between m-covered and m-uncovered areas can be observed. The stained sections were graded under the microscope by professional histology researchers using the Osteoarthritis Research Society International (OARSI) scoring system. 30 The total OARSI score is the sum of the tibial plateau and the femoral condyle. Scores in each quadrant range from 0 to 6. The new OARSI grading system provides useful information about the functional properties of cartilage. There is a significant difference in cartilage stiffness between samples with intact surface and no signs of degeneration (OARSI Grade 0) and samples with intact surface and early signs of arthritis (OARSI Grade … A semi-quantitative scoring system that could reasonably be employed in any basic cartilage histology laboratory was proposed.

OARSI histopathology grading and staging scores were determined in sham (control), and contralateral and ipsilateral treatments of both NM and FM groups of animals over 20 weeks. Tibial joint surfaces from (a) sham and (b) contralateral and ipsilateral treatments were assessed independently of femoral (c) sham and (d) contralateral and ipsilateral joint surfaces.
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Obesity is a known major risk factor for OA, which is attributed to the low-grade systemic inflammation that is caused by obesity-associated metabolic syndrome. One of the major risk factors for OA is meniscectomy (Mx) that causes a rapid and progressive OA. Mx has been employed in various animal models, especially in large ones, to study preclinical safety and strategy effectiveness to counteract OA. The aim of the present study is to review in vivo studies, performed in sheep and published in the last ten years.

This presents a challenge to score interpretation if a person is unable to cover the set distance (i.e., can only walk 20/40 m) as there is no longer a denominator for the test and a score of zero is essentially missing data. 2010-10-01 · Safranin-O photomicrographs showing the MFC (above) and MTP (below) and the medial meniscus (left), displaying a variety of OA severity and semi-quantitative scores.
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Kondroskyddare vid behandling av degenerativa-dystrofiska

The dynamic modulus significantly (p < 0.001) decreased with each advancing grade of degeneration from OARSI Grade 0 (surface intact) to OARSI Grade 4 (erosion). For the aggregate modulus, there were significant (p < 0.001) differences between OARSI Grade 0 and OARSI Grade 1 as well as between OARSI Grade 1 and OARSI Grade 2. Mean OARSI scores ± standard error are shown. Significantly higher scores were observed in NM contralateral femurs than NM sham femurs at 2 and 12 weeks (statistics not shown).